Pharmacokinetics and pharmacodynamics of ()-sotalol in healthy male volunteers
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چکیده
منابع مشابه
Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics
Preclinical studies show that GABA exerts anti-diabetic effects in rodent models of type 1 diabetes. Because little is known about its absorption and effects in humans, we investigated the pharmacokinetics and pharmacodynamics of GABA in healthy volunteers. Twelve subjects were subjected to an open-labeled, three-period trial involving sequential oral administration of placebo, 2 g GABA once, a...
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Cefixime is a significant member of orally active third generation cephalosporin and has excellent activity against many pathogens. The virtual bioavailability of a newly industrial dispersible tablet as compared with a recognized identified formulation. An open-label, single-dose, randomized, 2-way crossover study was conducted in fasted healthy Iranian male volunteers. Eligible participa...
متن کاملPharmacokinetics and Pharmacodynamics of Hyaluronan Infused into Healthy Human Volunteers
The pharmacodynamics and elimination kinetics of escalating doses (1.5-12 mg/kg) of hyaluronan (HA) infusions were studied in healthy human volunteers. Metabolic breakdown of serum HA and associated adverse events were monitored throughout the study. The HA-binding capacities of circulating CD4+ and CD8+ T lymphocytes, CD19+ Blymphocytes and CD14+ peripheral blood monocytes (PBMC) were also qua...
متن کاملTreatment of fetal tachycardia with sotalol: transplacental pharmacokinetics and pharmacodynamics.
OBJECTIVES The aim of this study was to investigate the pharmacokinetics and pharmacodynamics of sotalol in the treatment of fetal tachycardia. BACKGROUND Maternally administered, intrauterine therapy of fetal tachycardia is dependent on the transplacental passage of the antiarrhythmic agent. METHODS In a prospective study of patients treated for fetal tachycardia with sotalol, concentratio...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1996
ISSN: 0306-5251,1365-2125
DOI: 10.1111/j.1365-2125.1996.tb00052.x